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Modification of CKB is associated with β-amyloid depositions and a loss of function of APOE as a scavenger for lipid peroxidation-derived aldehydes 202 as both APOE deletion 203 and high levels of lipid peroxidation products are associated with increased lipoxidative modifications of CKB, GS, vimentin and GFAP 204

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By understanding and repurposing these molecules, we can define a path toward building a new class of antimicrobial compounds that specifically target bacterial TrxR